Optima Lead ®

Identify Potent & Patentable Molecules in 18-24 Months

Optima Lead® is a fully integrated drug discovery service to identify potent, synthetically feasible and patentable leads in 18-24 months. Starting from existing data about the target when available, the software SARA is used to extract usable information and predictive QSAR/QSPR models. These models are then used in our MedChem Decision® technology jointly with the 3D structure of the target (when available), a fragment database and reaction rules to de novo design novel and potent scaffolds. The newly designed scaffolds are injected into EZ Design® for designing and profiling a library of 50 to 80 molecules around each new scaffold. The selected molecules are then sent to a chemistry lab for synthesis and biological testing.

Value Creation

• Synthetically feasible, patentable & PK/toxicology profiled lead series
  within 18-24 months cycle time, including 2-3 iterations
• Current success: 10-20% hit-rate in 4 projects
• IP created belongs to the client
• Valuable ROI for our clients